Lung, Heart, Skin, Other:: Small cell carcinoma Classification Note Although it is possible to distinguish a number of different histological sub-classes of lung cancer by light microscopy, the most important current clinical distinction is between small cell lung cancer SCLC and non-small cell lung cancer NSCLC. Based primarily on its clinical behaviour, SCLC, a neuroendocrine lesion, is considered as a separate entity to the non-small cell carcinomas. The disease has a particularly aggressive clinical course with widespread early metastasis and somewhat in contrast to NSCLC, tumours will frequently show a short term response to cytotoxic chemotherapy and radiotherapy.
For practical reasons, small cell lung cancer SCLC is usually staged as either limited or extensive. In most cases, SCLC has already spread by the time it is found even if the spread is not seen on imaging testsso chemotherapy chemo is usually part of treatment if a person is healthy enough. If you smoke, one of the most important things you can do to be ready for treatment is to try to quit.
Treating limited stage SCLC Stage I cancers If you only have one small tumor in your lung and there is no evidence of cancer in lymph nodes or elsewhere, your doctors may recommend surgery to remove the tumor and the nearby lymph nodes.
Very few patients with SCLC are treated this way. This is only an option if you are in fairly good health and can withstand having all or part of a lung removed. Before the operation, the lymph nodes in your chest will be checked for cancer spread with mediastinoscopy or other testsbecause surgery is unlikely to be a good option if the cancer has spread.
Surgery is generally followed by chemotherapy. If cancer is found in the lymph nodes that were removed, radiation therapy to the chest is usually advised as well. The radiation is often given at the same time as the chemo. Although this increases the side effects of treatment, it appears to be more effective than giving one treatment after the other.
You might not be given radiation therapy if you already have severe lung disease in addition to your cancer or other serious health problems. In about half of people with SCLC, the cancer will eventually spread to the brain if no preventive measures are taken. For this reason, you may be given radiation therapy to the head called prophylactic cranial irradiation, or PCI to try to prevent this.
The radiation is usually given in low doses.
Still, some patients may have side effects from the radiation. If you are in good health, the standard treatment is chemo plus radiation to the chest given at the same time called concurrent chemoradiation. The chemo drugs used are usually etoposide plus either cisplatin or carboplatin.
Concurrent chemoradiation can help people with limited stage SCLC live longer and give them a better chance at cure than giving one treatment or one treatment at a time.
The downside is that this combination has more side effects than either chemo or radiation alone, and it can be hard to take. This may be followed by radiation to the chest. If no measures are taken to prevent it, about half of people with SCLC will have cancer spread to their brain.
If your cancer has responded well to initial treatment, you may be given radiation therapy to the head called prophylactic cranial irradiation, or PCI to try to prevent this.
The radiation is usually given in lower doses than what is used if the cancer had already spread to brain, but some patients may still have side effects from the radiation.
Most people treated with chemo with or without radiation for limited stage SCLC will have their tumors shrink significantly. In many, the cancer will shrink to the point where it can no longer be seen on imaging tests. Unfortunately, for most people, the cancer will return at some point.
Because these cancers are hard to cure, clinical trials of newer treatments may be a good option for some people. If you think you might want to take part in a clinical trial, talk to your doctor.
If you have extensive SCLC and are in fairly good health, chemotherapy chemo can often shrink the cancer, treat your symptoms, and help you live longer. The most common chemo combination is etoposide plus either cisplatin or carboplatin. Most people will have their cancer shrink significantly with chemo, and in some the cancer may no longer be seen on imaging tests.
Unfortunately, the cancer will still return at some point in almost all people with extensive stage SCLC. If the cancer responds well to chemo, radiation treatments to the chest may be given. This can help people with extensive stage SCLC live longer.
Radiation to the brain known as prophylactic cranial irradiation, or PCI may also be considered to help prevent cancer progression in the brain. Because these cancers are hard to treat, clinical trials of chemotherapy drugs and combinations, as well as other new treatments, may be a good option for some people.
If you think you might be interested in taking part in a clinical trial, talk to your doctor. If cancer growth within the lungs is causing symptoms such as shortness of breath or bleeding, radiation therapy or other types of treatment, such as laser surgery, can sometimes be helpful radiation therapy can also be used to relieve symptoms if the cancer has spread to the bones or brain.
If your overall health is poor, you might not be able to withstand the side effects of standard doses of chemo. This would include treatment of any painbreathing problems, or other symptoms you might have.If you have small cell lung cancer or are close to someone who does, knowing what to expect can help you cope.
Here you can find out all about small cell lung cancer, including risk factors, symptoms, how it is found, and how it is treated.
Sep 07, · Small cell lung cancer (SCLC), previously known as oat cell carcinoma, is considered distinct from other lung cancers, which are called non–small cell lung cancers (NSCLCs) because of their clinical and biologic characteristics.
See the image below. High-power photomicrograph of small cell. NSCLC is any type of epithelial lung cancer other than small cell lung cancer (SCLC). The most common types of NSCLC are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma, but there are several other types that occur less frequently, and all types can occur in unusual histologic variants.
Imfinzi approved in Japan for unresectable Stage III non-small cell lung cancer. Case Study Non-Small Cell Lung Cancer Alex urbanagricultureinitiative.comr, MD California Cancer Care Marin County, CA. History & Physical z59 yo female fell in 11/07 and sustained a zBy imaging studies, patient has T2N2, stage IIIA NSCLC: zQuestions: zIs her staging complete?
Does she need a. Small cell lung cancer is a very aggressive form of lung cancer.
Learn about small cell lung cancer symptoms, risk factors, diagnosis, and treatment.